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KMID : 0370019930070000005
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Chung-Ang Journal of Pharmacal Sciences
1993 Volume.7 No. 0 p.5 ~ p.12
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Comparative Studies on the Antidiabetic Activities of Ginseng Radices
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Abstract
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This study was attempted to compare the antidiabetic activities of Ginseng Radices on the hyperglycemia induced by Streptozotocin in rats.
The buthanol fractions of roots of Ginseng Radices were administered before and after injection of streptozotocin (50mg/kg,i.p.), and then blood glucose, serum cholesterol, and serum triglyceride levels were determined at 96 hours after streptozotocin injection.
1. The blood glucose levels in streptozotocin-induced hyperglycemic rats were dose-dependently decreased by the administration of buthanol frations of the Ginseng Radices. The administration of the buthanol frations(400mg/kg,P.O.) of Ginseng Radix alba and Ginseng Radix palva were significantly shown to decreased blood glucose level comparing with streptozotocin control group.
2. The serum total cholesterol levels in streptozotocin-induced hyperglycemic rats were significantly decreased by the administrations of the buthanol fractions(400mg/kg,P.O.) of Ginseng Radix aquosa and Ginseng Radix alba and Ginseng Radix palva.
But the buthanol fraction (200mg/kg,P.O.) of Ginseng Radix alba and the buthanol fractions (100,200,400mg/kg) of Ginseng Radix rubra were slightly decreased.
3. The serum triglyceride levels of streptozotocin-induced hyperglycemic rats were significantly decreased by the administration all of the four Ginseng Radices (100,200,400mg/kg,p.o.).
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